Diffusion Kurtosis Imaging in Prostate Cancer
نویسندگان
چکیده
Introduction: Diffusion weighted imaging (DWI) and the calculated apparent diffusion coefficient (ADC) is showing potential for improving detection of prostate cancer (PCa), as the increased cellularity of many tumors is associated with restricted water diffusion and thus with a decreased ADC [1,2]. The ADC assumes Gaussian water diffusion and is calculated by monoexponential fitting. However, the water diffusion is non Gaussian if restrictions are present. Diffusion kurtosis imaging (DKI), which is an extension of conventional DWI, is a promising tool to visualize non Gaussian water diffusion and thus can provide a specific measure of tissue structure, such as cellular compartments and membranes [3,4]. To the best of our knowledge, DKI has not been performed in the prostate yet. Therefore the aim of this study was to investigate the influence of restricted diffusion in PCa using diffusion kurtosis imaging.
منابع مشابه
Detection and Grading of Prostate Cancer using Diffusion Weighted Imaging: Kurtosis versus ADC
Fig. 3: Kapp: boxplot diagram of PCa (dotted line) and contralateral (line) areas. 4450 Detection and Grading of Prostate Cancer using Diffusion Weighted Imaging: Kurtosis versus ADC Matthias C. Roethke, Tristan Kuder, Timur H. Kuru, Boris Hadaschik, Michael Fenchel, Frederik Laun, and Bram Stieltjes Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Medical Physics, German C...
متن کاملبررسی ارزش Diffusion Weighted Imaging در تصاویر MRI برای تشخیص سرطان پروستات
Background: Prostate cancer is the third leading cause of death and is the most common cause of cancer in elderly men. Regarding to the low accuracy of screening methods such as prostate-specific antigen (PSA), Digital Rectal Examination (DRE) and trans rectal ultrasound (TRUS) in detection and localization of tumor, Magnetic Resonance Imaging (MRI) and Diffusion Weighted Imaging (DWI) attracte...
متن کاملDiffusion weighted imaging of the prostate—principles, application, and advances
This review article aims to provide an overview on the principles of diffusion-weighted magnetic resonance imaging (DW-MRI) and its applications in the imaging of the prostate. DW-MRI with regards to different applications for prostate cancer (PCa) detection and characterization, local staging as well as for active surveillance (AS) and tumor recurrence after radical prostatectomy (RP) will be ...
متن کاملSignal Intensity of High B-value Diffusion-weighted Imaging for the Detection of Prostate Cancer
Background: Diffusion-weighted imaging (DWI) is a main component of multiparametric MRI for prostate cancer detection. Recently, high b value DWI has gained more attention because of its capability for tumor characterization. Objective: To assess based on histopathological findings of transrectal ultrasound (TRUS)-guided prostate biopsy as a reference, an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010